Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, can have serious health implications if left untreated. In Siddha medicine, an ancient healing system originating from India, syphilis is considered to be caused by an imbalance in the body’s doshas, particularly the Pitta and Kapha doshas, which govern metabolic processes and immunity. Siddha practitioners approach the treatment of syphilis holistically, aiming to restore the balance of these doshas and eradicate the infection. Herbal remedies form a vital component of Siddha treatment, with formulations containing ingredients like neem, turmeric, and licorice, known for their antibacterial, anti-inflammatory, and immune-boosting properties. These herbs help combat the bacterial infection, reduce inflammation, and strengthen the body’s natural defenses. Siddha medicine also emphasizes dietary modifications, encouraging patients to consume a balanced diet rich in nutrients to support the immune system’s response. Additionally, practitioners may recommend specific lifestyle changes, including stress-reducing techniques such as yoga and meditation, to enhance overall well-being. By addressing the root cause through herbal remedies, dietary adjustments, and lifestyle modifications, Siddha medicine offers a natural and comprehensive approach to managing syphilis, aiming to eliminate the infection, alleviate symptoms, and improve the overall health of individuals affected by this condition.